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APATINIB: A PROMISING ORAL ANTIANGIOGENIC AGENT IN THE TREATMENT OF MULTIPLE SOLID TUMORS
저자 : 미국 콜로라도 암센터 혈액종양학과 A.J. Scott, W.A. Messersmith and A. Jimeno
출처 : Drugs Today 2015, 51(4): 223
Aberrant proangiogenic pathways have long been implicated in tumorigenesis and metastasis. Antiangiogenic therapies have shown efficacy in the treatment of a variety of solid tumors including lung, breast, colon, glioblastomas, and other solid tumor types. Apatinib, a small-molecule inhibitor of vascular endothelial growth factor receptor-2 (VEGFR-2), is an orally bioavailable agent currently being studied in multiple tumor types. Apatinib has shown a survival benefit in gastric cancer in a phase III trial and non-small cell lung cancer in a phase II trial. With a favorable side effect profile and improved outcomes, apatinib has demonstrated a substantial potential to augment therapeutic options in a variety of tumor types.